11/27/2023 0 Comments Carla cox united against poverty![]() Orange County United Way Presents "Orange County Evictions: A Landscape Analysis of Rent-Based Evictions and Housing Instability in Our Community".Orange County United Way Opens New SparkPoint OC Financial Empowerment Center at Kinoshita Elementary School in San Juan Capistrano.United Way 2023 Real Cost Measure Study Finds 33% of Orange County Households Fall Below Poverty Line.Orange County United Way’s OC Free Tax Prep Program Results in $19.3 Million Local Impact.United to End Homelessness Reaches WelcomeHomeOC Milestone, Ending Homelessness for 900 Orange County Neighbors Since 2019.Orange County United Way Acquires 2-1-1 Orange County.Hotline 2-1-1 Orange County is now under Orange County United Way.UC Irvine Poll: Homelessness, Affordable Housing Top Concerns in OC.Orange County United Way Elects New Officers and Five New Members to its Board of Directors.United to End Homelessness, an Orange County United Way Initiative, Partners with UCI to Prompt Solutions on Affordable Housing and Homelessness in Orange County.Orange County United Way Names Elizabeth Andrade as Executive Director for 2-1-1 Orange County.Annual Alexis de Tocqueville Society Fall Fundraiser.Donate to Help End Human Trafficking in OC.Brenyale Toomer-Byas Scholarship for Emerging Leaders.Help South OC Families Impacted by Covid-19.Eviction Diversion Efforts in Orange County. ![]() Commitment to Diversity, Equity, and Inclusion.© 2022 by The American Society of Hematology. This is the largest pooled analysis of clinical trials data validating POD24 as a robust indicator of poor FL survival and identified clinical predictors of early death and progression that can aid in building comprehensive prognostic models incorporating clinical and molecular predictors of POD24. In the time-dependent Cox model and the 24-month landmark analysis, POD24 was associated with poor subsequent OS (hazard ratio, 4.85 and 3.06, respectively). In a multivariable logistic regression model, male sex (odds ratio, 1.30), PS ≥2 (OR, 1.63), B2M (≥3 mg/L OR, 1.43), and high-risk FLIPI score (3-5 OR, 3.14) were associated with increased risk of progression before 24 months. Patients without progression at 24 months at baseline had favorable performance status (PS), limited-stage (I/II) disease, low-risk FL International Prognostic Index (FLIPI) score, normal baseline hemoglobin, and normal baseline β2 microglobulin (B2M) level. A landmark analysis evaluated the association of POD24 with OS for the subset of patients who were alive at 24 months after trial registration. Cox regression evaluated the association between POD24 as a time-dependent factor and subsequent overall survival (OS). Logistic regression models evaluated the association between clinical factors and POD24. We performed a pooled analysis of 13 randomized clinical trials of patients with FL in the pre- and postrituximab eras to identify clinical factors that predict POD24. Observational studies and stand-alone trials indicate that patients with follicular lymphoma (FL) who experience disease progression within 24 months of front-line chemoimmunotherapy (POD24), have poor outcomes. 15 Department of Lymphoma/Myeloma, MD Anderson Cancer Center, University of Texas, Houston, TX.14 Memorial Sloan-Kettering Cancer Center, NY and.13 Candiolo Cancer Institute, Fondazione del Piemonte per l'Oncologia-Istituto di Ricovero e Cura a Carattere Scientifico (FPO-IRCCS), Torino, Italy.Hoffmann-La Roche Ltd., Basel, Switzerland. 12 Pharma Development Clinical Oncology, F.10 Department of Hematology and Cell Therapy, University of Tours, Tours, France.8 Leiter Onkologisches Zentrum, Nordhäuser Strasse 74 99089 Erfurt, Germany.7 Karolinska Institutet, and Hematology Centre, Karolinska University Hospital, Stockholm, Sweden.6 Department of Haematology, Addenbrookes Hospital, Cambridge, United Kingdom.5 Department of Internal Medicine III, Ludwig-Maximilians University Hospital, Campus Grosshadern, Munich, Germany. ![]()
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